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2016 Fiscal Year Final Research Report

New strategy for critically ill patients by control of NETs

Research Project

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Project/Area Number 25293366
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypePartial Multi-year Fund
Section一般
Research Field Emergency medicine
Research InstitutionNagasaki University

Principal Investigator

TASAKI Osamu  長崎大学, 病院(医学系), 教授 (90346221)

Co-Investigator(Kenkyū-buntansha) 田島 吾郎  長崎大学, 病院(医学系), 助教 (00437427)
朝野 和典  大阪大学, 医学(系)研究科(研究院), 教授 (40202204)
嶋津 岳士  大阪大学, 医学(系)研究科(研究院), 教授 (50196474)
山野 修平  長崎大学, 病院(医学系), 助教 (60570538)
小倉 裕司  大阪大学, 医学(系)研究科(研究院), 准教授 (70301265)
廣瀬 智也  大阪大学, 医学(系)研究科(研究院), 助教 (70597509)
小島 将裕  大阪大学, 医学部附属病院, 医員 (70721091)
竹川 良介  大阪大学, 医学部附属病院, 医員 (30759577)
萩谷 英大  大阪大学, 医学部附属病院, 助教 (30718531)
松本 直也  大阪大学, 医学(系)研究科(研究院), 研究員 (50359808)
関 雅文  大阪大学, 医学部附属病院, 講師 (80432970)
濱口 重人  大阪大学, 医学部附属病院, 医員 (20735360)
入澤 太郎  大阪大学, 医学(系)研究科(研究院), 研究員 (50379202)
Research Collaborator YAMAMOTO Norihisa  
Project Period (FY) 2013-04-01 – 2017-03-31
KeywordsNETs
Outline of Final Research Achievements

In this study, we clarified dynamic changes of NETs in critically ill patients. First, length of NETs significantly increased on day 1 compared to day 0(the day of infection), and decreased on day 6-8 compared to day 1. In the other study, we took blood samples from intubated patients on admission to Intensive Care Unit, and determined the existence of NETs or citrullinated histon H3(Cit-H3)、which is involved in NETs formation. The existence of NETs or Cit-H3 was observed more often in patients with the presence of bacteria in tracheal aspirates. These results are suggesting that NETs are associated with infection control, and the possibility of treatment by control of NETs or Cit-H3 in patients with critically ill condition.

Free Research Field

救急医学

URL: 

Published: 2018-03-22  

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