Association between atherosclerosis, cognitive impairment and masticatory dysfunction: Interaction of genetic factors

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293394
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Osaka University
• Principal Investigator: Maeda Yoshinobu 大阪大学, 歯学研究科(研究院), 教授 (10144510)
• Co-Investigator(Kenkyū-buntansha): IKEBE Kazunori 大阪大学, 大学院歯学研究科, 准教授 (70273696) ; KAGAWA Ryosuke 大阪大学, 歯学部附属病院, 医員 (40448147) ; OKADA Tadashi 大阪大学, 歯学部附属病院, 医員 (60733186) ; GONDO Yasuyuki 大阪大学, 人間科学研究科, 准教授 (40250196) ; KAMIDE Kei 大阪大学, 医学系研究科, 教授 (80393239)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 高齢者歯科 / 咀嚼機能 / 循環器系疾患 / 認知機能 / 遺伝因子

Outline of Final Research Achievements

Our epidemiological study of community-dwelling old population showed that number of residual teeth and periodontal pocket depth were significantly associated with hypertension and cognitive function. Additionally, number of remaining teeth and periodontal pocket depth had significant associations with several SNPs related to cardiovascular diseases or dementia. Any general linear models with cardiovascular diseases or a cognitive decline as dependent variables didn’t showed a significant interaction between the genetic factor and oral status.
The results suggested common genetic factors between oral diseases and cardiovascular diseases or cognitive impairment.

Free Research Field

歯科補綴学