Development of Chemically Defined Culture Substrate for Cell Proliferation and Differentiation

2015 Fiscal Year Final Research Report

• Project/Area Number: 25293403
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Hiroshima University
• Principal Investigator: Hirata Isao 広島大学, 医歯薬保健学研究院(歯), 助教 (40346507)
• Co-Investigator(Kenkyū-buntansha): KANAWA Masami 広島大学, 自然科学研究支援開発センター, 助教 (00284208) ; KATO Koichi 広島大学, 大学院医歯薬保健学研究院(歯), 教授 (50283875) ; KATO Yukio 広島大学, 大学院医歯薬保健学研究院(歯), 研究員 (10112062)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 再生医学 / 表面・界面物性 / 細胞・組織 / ナノ薄膜

Outline of Final Research Achievements

A study of cell culture substrates requires the technology of the surface physical chemistry in addition to biology, so these progresses are slow. However this research is very important because the scaffold on which cells to live. This study was aimed precise control of proliferation and differentiation of cells, we developed a chemically defined culture substrate whose surface precisely controlled in nano-order. In particular cause of improvement of proliferation of mesenchymal stem cells on well-defined substrate, it has been suggested to be due to the maintenance of stemness.

Free Research Field

生体材料学