2015 Fiscal Year Final Research Report
Patient-derived dental pulp stem cell-based innovation for disease mechanism and therapeutic development in cleft lip palate
| Project/Area Number |
25293405
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAZA Haruyoshi 九州大学, 大学院歯学研究院, 講師 (30336151)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 歯髄幹細胞 / 口唇口蓋裂 / 患者由来幹細胞 |
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| Outline of Final Research Achievements |
In this project, we evaluated that CL/P patient-derived SHED expressed an enhanced phosphorylation of ERK1/2 to suppress their regenerative capacity to form bone tissue. The enhancement of ERK1/2 in CL/P patient-derived SHED was caused by hypomethylation of DUSP4 and 6 DNA promoters. The inhibited bone regenerative capacity in CL/P patient-derived SHED was rescued by inhibition of ERK1/2 phosphorylation. These findings suggested that, in future, a promising therapeutics with autologous SHED-based bone regeneration will be developed in CL/P treatment.
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| Free Research Field |
口腔解剖学
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