2016 Fiscal Year Final Research Report

Development of an innovative communication support device for amyotrophic lateral sclerosis based on the underlying pathophysiology and long-term follow-up assessment

Research Project

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Project/Area Number	25293449
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Partial Multi-year Fund
Section	一般
Research Field	Clinical nursing
Research Institution	Tokyo Metropolitan Institute of Medical Science
Principal Investigator	NAKAYAMA Yuki 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, プロジェクトリーダー (00455396)
Co-Investigator(Kenkyū-buntansha)	小柳清光信州大学, 医学部, 教授 (00134958) 清水俊夫公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 研究員 (50466207) 長尾雅裕公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 研究員 (60466208) 望月葉子公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 研究員 (80267054) 長谷川良平国立研究開発法人産業技術総合研究所, 人間情報研究部門, 研究グループ長 (00392647)
Co-Investigator(Renkei-kenkyūsha)	MATSUDA Chiharu 公益財団法人東京都医学総合研究所, 運動感覚システム研究分野, 研究員 (40320650) KOMORI Takashi 公益財団法人東京都医学総合研究所, 脳発達再生研究分野, 研究員 (90205526)
Project Period (FY)	2013-04-01 – 2017-03-31
Keywords	筋萎縮性側索硬化症 / 神経科学 / 難病看護学 / 意思伝達支援 / 生体信号
Outline of Final Research Achievements	Our progress was made as a result of this project as fellows, First we identified predictors of impaired communication stage. Second, developed the concept of “adverse clinical signs” to delineate a group of conditions that compromise effective communication. Third, brain imaging studies of the relationship between the tegmentum and communication stages showed that atrophy of the periaqueductal gray matter is typically associated with Stage V disease (TLS). Fourth, brain imaging studies of the relationship between the tegmentum and communication stages showed that atrophy of the periaqueductal gray matter is typically associated with Stage V disease (TLS). Fifth, evaluation of somatosensory and visually evoked potentials in Stage V patients suggested that the visual pathway is less prone to degeneration than somatosensory and auditory pathways in advanced ALS patients, who have damage to a variety of neural systems, including the motor neurons.
Free Research Field	難病看護