2016 Fiscal Year Final Research Report
Distribution of antimicrobial brominated biphenols produced by marine biota in southeast Asia
| Project/Area Number |
25303011
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Partial Multi-year Fund |
|---|
| Section | 海外学術 |
|---|
| Research Field |
Green/Environmental chemistry
|
|---|
| Research Institution | Daiichi University, College of Pharmaceutical Sciences |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
小瀧 裕一 北里大学, 水産学部, 准教授 (30113278)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
ENDO Tetsuya 北海道医療大学, 薬学部, 准教授 (10133216)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 海藻 / 臭素化合物 / 起源 |
|---|
| Outline of Final Research Achievements |
The origin of naturally produced brominated biphenyls (OH-BDE) was found in brown algae (Sargassum sp.) and bivalve (Spondylus sp.) in Southeast Asia (Philippines, Indonesia). Genetic analysis indicated the marine bacteria (Pseudoanteromonus sp) in the algae could produce OH-BDE, which are further methylated to methoxy metabolites (MeO-BDE) and accumulate in higher trophic organisms. Secondary metabolites (hydroxylated dioxins) during this process were found and partly distributed in fish. Human exposure to MeO-BDE may be readily metabolized in liver to OH-BDE by CYP2B6, which are retained in blood.
|
| Free Research Field |
環境科学
|
