Development of diagnostic methods for viral zoonoses derived from wild animals and birds and the comparative epidemiological study of the viral zoonones

2016 Fiscal Year Final Research Report

• Project/Area Number: 25304040
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 海外学術
• Research Field: Veterinary medical science
• Research Institution: Hokkaido University
• Principal Investigator: KARIWA Hiroaki 北海道大学, (連合)獣医学研究科, 教授 (70224714)
• Co-Investigator(Kenkyū-buntansha): 有川 二郎 北海道大学, 医学(系)研究科(研究院), 教授 (10142704) ; 好井 健太朗 北海道大学, (連合)獣医学研究科, 准教授 (50421988) ; 森松 組子 (吉松組子) 北海道大学, 医学(系)研究科(研究院), 准教授 (90220722)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 人獣共通感染症 / ウイルス / ハンタウイルス感染症 / ダニ媒介性脳炎 / ウエストナイル熱 / 診断法 / 疫学

Outline of Final Research Achievements

In this study, simple diagnostic methods were developed for zoonoses, such as hantavirus infections, tick-borne encephalitis, and West Nile fever, which are severe and fatal diseases, and are considered as major problems in many countries. ELISA and immunochromatography were developed to detect anti-hantavirus antibodies in various rodents. ELISA systems using viral-like particles (SPs) of tick-borne encephalitis virus conjunctive with IgG and Strep-tag were established. A stable reverse genetics system for West Nile virus was developed by using homologous recombination.

Free Research Field

公衆衛生学