Surveys on factors of onset and progression for CKDue in Sri Lanka

2016 Fiscal Year Final Research Report

• Project/Area Number: 25305021
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 海外学術
• Research Field: Hygiene and public health
• Research Institution: Kyoto University
• Principal Investigator: HARADA KOUJI 京都大学, 医学(系)研究科(研究院), 准教授 (80452340)
• Co-Investigator(Kenkyū-buntansha): 小泉 昭夫 京都大学, 医学(系)研究科(研究院), 教授 (50124574)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 環境衛生学 / 分析化学 / 国際保健 / 慢性腎臓病 / 疫学

Outline of Final Research Achievements

In Sri Lanka in South Asia, chronic kidney disease has rapidly increased in the eastern part and the northern part of the island of Ceylon since the 1990s. We have investigated possible candidate agents and genetic factors. SLC13A3, KCNJ10 and LAMB2 were found to be possible candidates. Aristolochia has been used as a plant biologics with renal toxicity. In order to investigate the involvement, the urine was assayed for alistolochic acid. As a result, no detectable amount of the alistolochic acid was found. Also neonicotinoid was analyzed to reveal exposure to pesticide, while there was no difference between case and controls. And electron microscopic observations of the histological tissues were performed.The observation of electron microscopic observation of renal tissues showed no evidence supporting the heavy metal toxicity in the pathogenesis of CKDu .

Free Research Field

衛生学