Management of Helicobacter infection and its related gastrointestinal diseases in Asia

2015 Fiscal Year Final Research Report

• Project/Area Number: 25305027
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 海外学術
• Research Field: Gastroenterology
• Research Institution: Kobe University
• Principal Investigator: AZUMA Takeshi 神戸大学, 医学(系)研究科(研究院), 教授 (60221040)
• Co-Investigator(Kenkyū-buntansha): HOSHI Namiko 神戸大学, 医学部附属病院, 助教 (40645214) ; MORITA Yoshinori 神戸大学, 医学部附属病院, 講師 (60420460)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: へリコバクターピロリ菌 / ヘリコバクタースイス菌 / 胃がん / 胃マルトリンパ腫

Outline of Final Research Achievements

Helicobacter pylori CagA protein is considered to be one of the virulence factors associated with gastric cancer. Two major subtypes of CagA have been observed, the Western and East Asian types. The prevalence of the East Asian CagA-positive strain is associated with the mortality rate of gastric cancer in Asia. A phylogenetic tree of concatenated well-defined core genes supported divergence of the East Asian lineage from the European lineage ancestor, and then from the Amerind lineage ancestor. Greater divergence was observed in the genes of outer membrane proteins and lipopolysaccharide synthesis.
Helicobacter suis infects the stomachs of both animals and humans, and can induce gastric mucosa-associated lymphoid tissue lymphomas. CXCL13 was highly expressed in the Helicobacter-infected mice and gastric MALT lymphoma patients. CXCL13　neutralization interfered with the formation of gastric lymphoid follicles.

Free Research Field

医歯薬学