Research on membranous nephropathy in Asia Pacific region

2015 Fiscal Year Final Research Report

• Project/Area Number: 25305028
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 海外学術
• Research Field: Kidney internal medicine
• Research Institution: Nagoya University
• Principal Investigator: Maruyama Shoichi 名古屋大学, 医学(系)研究科(研究院), 准教授 (10362253)
• Co-Investigator(Kenkyū-buntansha): MATSUO Seiichi 名古屋大学, 医学系研究科, 教授 (70190410) ; YUZAWA Yukio 藤田保健衛生大学, 医学部, 教授 (00191479) ; INOUE Itsuro 国立遺伝が研究所, 総合遺伝研究系, 教授 (00192500) ; YAMAMOTO Ryohei 大阪大学, 保健センター, 講師 (00533853) ; AKIYAMA Shin'ichi 名古屋大学, 医学系研究科, 特任講師 (20500010) ; YOKOYAMA Hitoshi 金沢医科大学, 医学部, 教授 (50191531) ; TSUBOI Naotake 名古屋大学, 医学部附属病院, 講師 (50566958) ; SATO Waichi 名古屋大学, 医学部附属病院, 講師 (90508920) ; KATSUNO Takayuki 名古屋大学, 医学部附属病院, 病院助教 (60642337)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 膜性腎症 / PLA2R / 遺伝子型 / ネフローゼ症候群 / アジア

Outline of Final Research Achievements

In order to clarify the characteristic of the idiopathic membranous nephropathy (iMN), I investigated the situation of the iMN patients in Japan and in countries of the Asia-Pacific region. The positive rate of PLA2R antibodies was 53% in patients with iMN and 0% in patients with secondary MN. The rate in Japan was lower than that in Korea or China. The genetic polymorphism analysis revealed a significant association in rs4664308 of PLA2R1 in iMN patients, but no relationship was observed in rs2187668 of HLA-DQA1. It is possible that the regional difference as well as genetic difference may contribute the mechanism of the PLA2R antibody generation in the iMN patients.

Free Research Field

腎臓内科学