International research project studying common cystatin C GFR estimating equation for Asian subjects

2016 Fiscal Year Final Research Report

• Project/Area Number: 25305029
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Partial Multi-year Fund
• Section: 海外学術
• Research Field: Kidney internal medicine
• Research Institution: Osaka University
• Principal Investigator: Horio Masaru 大阪大学, 医学(系)研究科(研究院), 准教授 (20273633)
• Co-Investigator(Kenkyū-buntansha): 安田 宜成 名古屋大学, 医学(系)研究科(研究院), 准教授 (60432259) ; 高原 史郎 大阪大学, 医学(系)研究科(研究院), 教授 (70179547)
• Research Collaborator: Lee Ho Yung ; Kim Yon SU ; Chen Hung-Chun ; Tungsanga Krinag ; Jha Vivekhand
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: GFR推算式 / アジア人 / シスタチンC / クレアチニン / 国際情報交換

Outline of Final Research Achievements

Glomerular filtration rate (GFR) estimating equations are generally used for assessment of kidney function that is important for diagnosis of kidney disease. GFR equations based on serum creatinine and cystatin C developed from Japanese subjects are commonly used in Japan. But, it is not clear that the GFR equations for Japanese subjects could be used in other Asian populations. Therefore, we studied with Taiwan, Korea, Thai and India researchers and collected 273, 277, 28 and 130 measured GFR data, respectively. We analyzed the accuracy of the Japanese GFR equations in these Asian populations. Performance of the GFR equation based on serum creatinine varied according to race. The equation underestimated and overestimated GFR in Taiwan and Indian subjects, respectively. On the other hand, the GFR equation based on serum cystatin C showed better performance and acceptable accuracy in the Asian populations. It could be used as a single common GFR equation fit for Asians.

Free Research Field

腎臓病学