2015 Fiscal Year Annual Research Report
Comprehensive Assessment of Prevalence and Trends of Gestational Diabetes Mellitus among Bangladeshi Rural Women: A multidisciplinary investigation from basic epidemiology to genetic screening
| Project/Area Number |
25305034
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
水谷 太郎 筑波大学, 医学医療系, 教授 (80181890)
岡崎 修 国立研究開発法人国立国際医療研究センター, 循環器内科, 医長 (30203970)
岩嶋 義雄 国立研究開発法人国立循環器病研究センター, 高血圧・腎臓科, 医長 (80448068)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 妊娠中糖尿病 / バングラデシュ / 疫学 / 遺伝学 |
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| Outline of Annual Research Achievements |
The prevalence of GDM of Bangladeshi women is 11.5% (urban) and 10.8% (rural) which is statistically non-significant. Prevalence of GDM increases with the increase number of parity. In our study population we found that prevalence of GDM increases with increase of maternal age. Mean blood pressure did not alter in pregnant women with or without GDM in Bangladesh. Percentage of metabolic profile parameters among GDM cases in Bangladesh: high LDL-C (25.8%); low HDL-C (65.5%); hypertriglyceridemia (55.5%); hypercholesterolemia (26.4%); and metabolic syndrome (35.4%). GDM positive cases have 11.62% positive family history of diabetes. More than 90% rural pregnant women in Bangladesh do not know about GDM. Still in Bangladesh, in rural context, around half of the pregnant women do not receive antenatal care. Still the acceptance of institutional delivery rate is very low in rural Bangladesh. Top ranked risk factors for GDM: hypertension, metabolic syndrome, family history of hypertension, family history of diabetes, lack of regular exercise, lack of education, lack of health awareness and increased age in this population. Vascular endothelial growth factor (VEGF) which is now a potential therapeutic and diagnostic target for various diabetic complications is significantly higher in GDM positive cases compared to GDM negative cases. The present study is the first report describing the prevalence of GDM among Bangladeshi rural women and calls for urgent action to stop and prevent the diabetes development in pregnancy and the associated complications both for mother and child.
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| Research Progress Status |
27年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
27年度が最終年度であるため、記入しない。
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| Causes of Carryover |
27年度が最終年度であるため、記入しない。
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| Expenditure Plan for Carryover Budget |
27年度が最終年度であるため、記入しない。
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[Journal Article] Assessment of Circulatory Levels of Endothelin-1 in Diabetic Subjects Screened Through a Cross Sectional Study from Rural Women in Bangladesh2015
Author(s)
M.A. Rahman, S. Jesmin, C.N. Mowa, F. Sohael, J. Kamiyama, A.K.M.A. Habib, N. Shimojo, M.M. Islam, M. Moroi, O. Okazaki, N. Yamaguchi, S. Kawano, T. Mizutani, Y. Iwashima
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Journal Title
International Journal of Diabetes and Clinical Research
Volume: 2
Pages: 1-5
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Nationwide Non-Communicable Disease Risk Factors Profile in Bangladesh.2015
Author(s)
S. Jesmin, M.A. Rahman, A.K.M.A. Habib, M.M. Islam, S.N. Sultana, S. Zaedi, T. Khatun, F. Sohael, N. Yamaguchi, O. Okazaki, Y. Iwashima, S. Kawano.
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Journal Title
Journal of Hypertension
Volume: 33
Pages: 2
DOI
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Assessment of Circulatory Endothelin-1 Level among Preand Post-Menopausal Rural Women in Bangladesh: Result from a Population-Based Study.2015
Author(s)
T. Khatun, S. Jesmin, N. Yamaguchi, J. Kamiyama, S. Akter, S.N. Sultana, M.M. Islam, O. Okazaki, S. Kawano, H. Akashi, T. Mizutani, T. Miyauchi, M.A. Rahman, A.K.M. A. Habib
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Journal Title
Annals of Vascular Medicine and Research
Volume: 2(2）
Pages: 1014 (1-7)
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Higher circulatory level of endothelin-1 in hypertensive subjects screened through a cross-sectional study in rural Bangladeshi women2015
Author(s)
S. Akter, S. Jesmin, Y. Iwashima, H. Sakuramoto, M.A. Rahman, M.M. Islam, T. Khatun, M. Moroi, T. Miyauchi, S. Kawano, T. Mizutani, Y. Kawano.
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Journal Title
Hypertension Research
Volume: 38(3)
Pages: 208-212
DOI
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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