2016 Fiscal Year Final Research Report
Chemopreventive intervention study and miRNA monitoring of oral cancer in Sri Lanka
| Project/Area Number |
25305036
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Partial Multi-year Fund |
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| Section | 海外学術 |
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| Research Field |
Surgical dentistry
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
Chiba Itsuo 北海道医療大学, 歯学部, 教授 (50250460)
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| Co-Investigator(Kenkyū-buntansha) |
松岡 紘史 北海道医療大学, 歯学部, 講師 (50598092)
安彦 善裕 北海道医療大学, 歯学部, 教授 (90260819)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | betel quid / 口腔がん / スリ・ランカ / 介入試験 / cur cumin / MMP-9 |
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| Outline of Final Research Achievements |
We have established cell culture model for analyzing epigenetic changes caused by arecoline, one of ingredients of betel quid. Using DNA microarray analysis and bioinformatics analysis, we clarified that mRNA level of MMP-9 was elevated and curcumin suppressed the mRNA level.
Chemopreventive intervention study has started in the tea estates of Sri Lanka. Because of the short period of observation, we have not got the results.
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| Free Research Field |
口腔衛生学、予防歯科学、腫瘍学
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