Analysis of cancer attractors on gene expression potentials by gene-environment (GxE) interactions

2015 Fiscal Year Final Research Report

• Project/Area Number: 25330333
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Life / Health / Medical informatics
• Research Institution: Tohoku University
• Principal Investigator: OGISHIMA Soichi 東北大学, 東北メディカル・メガバンク機構, 准教授 (40447496)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 生命情報 / 癌アトラクター

Outline of Final Research Achievements

Toward systems-level understanding of transition of cancer attractors, we clarified cancer attractors and their transitions on gene expression potential during epithelial-mesenchymal transition in cancer metastasis by analyzing time-course gene expression data. We conducted PCA on gene expression data to reduce their dimension, and inferred gene regulatory network regulating cancer attractors. As for cancer metastasis, we evaluated effects on gene expression potential by gene-environment (GxE) interactions, and clarified stability of cancer cells on gene expression potentials and trajectory of their attractors under certain condition of gene and environment.

Free Research Field

生体生命情報学