2015 Fiscal Year Final Research Report
The biological meaning of neurite outgrowth via bisphenol A and its receptor
| Project/Area Number |
25340104
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental risk control and evaluation
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| Research Institution | Kansai University |
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Principal Investigator |
SHIMOKE KOJI 関西大学, 化学生命工学部, 教授 (10351496)
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| Co-Investigator(Kenkyū-buntansha) |
IKEUCHI Toshihiko 関西大学, 化学生命工学部, 教授 (20093362)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | bisphenol A / PC12細胞 / 大脳皮質神経細胞 / エピジェネティクス |
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| Outline of Final Research Achievements |
This research has been performed because of finding the neurite extending effect of bisphenol A(BPA), which belongs to endocrine disrupting chemicals. The research by others has been remitted to the sexual effect although ours focus on neurons. The results are that BPA induced neurite outgrowth with bipolarization on soma through histone H3 modification (acetylation) on specific lysine residue.
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| Free Research Field |
神経科学
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