Effect of probiotics on Nonalcholic fatty liver disease

2016 Fiscal Year Final Research Report

• Project/Area Number: 25350132
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits
• Research Institution: Okayama Prefectural University
• Principal Investigator: Kawakami Takayo (笹川貴代) 岡山県立大学, 保健福祉学部, 教授 (10254567)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: NAFLD / プロバイオティクス / 肥満

Outline of Final Research Achievements

We focused on anti-obesity effect of probiotics on progression of nonalcoholic fatty liver disease (NAFLD). In this study, we observed that visceral fat accumulation and NAS (NAFLD activity score) in obese mice fed with probiothics (Lactobacillus plantarum 301102) and prebiotics was significantly lower than control mice. We also showed that omega 3 fatty acid rich seal oil supplementation on NASH model mouse decreased NAS significantly. This study suggests that the anti-inflammatory and anti-obesity effect of L.plantaram and/or seal oil might be preservation of hepatic function in NAFLD. Further examination including mechanism of mediators from intestinal bacterial flora or adipose tissue on chronic liver disease should be performed.

Free Research Field

栄養学