Development of miniaturized glucose monitoring system by combining a needle-type glucose sensor with intravenous microdialysis sampling method for artificial endocrine pancreas

2015 Fiscal Year Final Research Report

• Project/Area Number: 25350532
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biomedical engineering/Biomaterial science and engineering
• Research Institution: Kumamoto University
• Principal Investigator: SHIMODA SEIYA 熊本大学, 生命科学研究部, 准教授 (60398203)
• Co-Investigator(Kenkyū-buntansha): FURUKAWA NOBORU 熊本大学, 大学院生命科学研究部, 准教授 (90335795) ; ARAKI EIICHI 熊本大学, 大学院生命科学研究部, 教授 (10253733)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 人工臓器工学 / 再生医工学

Outline of Final Research Achievements

We developed the glucose monitoring system by combining a need-type glucose sensor with an intravenous microdialysis sampling technique for long-term subcutaneous tissue. This system was tested both in vitro and in vivo. Response time to reach 90% of the final plateau value was calculated by swithching the probe from 100 to 200 mg/dL glucose. The overall correlation between blood glucose measured by this system (X) and blood glucose concentration (Y) was Y = 0.997X + 0.245 (r=0.952). Thus, the new glucose monitoring system developed is potentially suitable for clinical application.

Free Research Field

総合領域