Elucidation of the rehabilitation effects on nitric oxide and sympathetic nervous system

2015 Fiscal Year Final Research Report

• Project/Area Number: 25350590
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Tohoku University
• Principal Investigator: ITO DAISUKE 東北大学, 医学(系)研究科(研究院), 助教 (50466570)
• Co-Investigator(Kenkyū-buntansha): ITO Osamu 東北大学, 医学系研究科, 准教授 (00361072) ; KOHZUKI Masahiro 東北大学, 医学系研究科, 教授 (70234698)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 運動療法 / 一酸化窒素 / 交感神経 / 高血圧 / 腎臓

Outline of Final Research Achievements

The present study evaluated the effects of the chronic aerobic running exercise and renal denervation on blood pressure and renal nitric oxide (NO) system in spontaneously hypertensive rats (SHR). Rats were randomly divided into 4 groups, sham-operated, renal denervated, forced treadmill exercised (20 m/min, 60 min/day, 5 days/week, 8 weeks) and combined (renal denervation and exercise) groups.
Both renal denervation and exercise decreased, and the combination further decreased systolic blood pressure in SHR. Compared with sham-operated groups, other 3 groups indicated lower albumin secretion and higher creatinine clearance in SHR. Analysis of renal norepinephrin, nitric oxide system, oxidative stress and histology are in progress. To elucidate the mechanisms of effects of exercise, involvements of renal sympathetic nervous system and nitric oxide system, would elevate the evidence of beneficial effects of chronic aerobic exercise on hypertension.

Free Research Field

内部障害リハビリテーション（特に腎臓リハ、心臓リハ），高血圧学，腎臓病学，一酸化窒素，酸化ストレス