Influence of magnetic implant on trabecular bone and leg muscles in rats

2015 Fiscal Year Final Research Report

• Project/Area Number: 25350652
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Kio University
• Principal Investigator: Nishii Yasue 畿央大学, 健康科学部, 助手 (50461207)
• Co-Investigator(Kenkyū-buntansha): MINEMATSU Akira 畿央大学, 健康科学部, 教授 (50368601)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 静磁場 / ラット

Outline of Final Research Achievements

Static magnetic field (SMF) was reported to inhibit reduction of bone mineral density in ovariectomized (OVX) rats. The purpose of this study is to examine the influence of SMF on bone microarchitecture and leg muscles in OVX or denervated rats.
Final body weights of the OVX+MG and OVX groups were significantly heavier than the SHAM group. Trabecular bone microarchitecture was remarkably deteriorated by OVX. The ratio of decrease for bone volume fraction was 81% in the OVX group and 69% in the OVX+MG group compared with the SHAM group. Compared with the OVX group, the degree of deterioration was smaller and V*tr was significantly higher in the OVX+MG group. In this study, SMF was likely to inhibit deterioration of trabecular bone microarchitecture and decreases of the relative area of fast-twitch glycolytic fibers in rectus femoris in the animal model. We need to consider the SMF conditions, the timing and term of interventions.

Free Research Field

実験動物学