2015 Fiscal Year Final Research Report
Analysis of coronary artery blood flow in diabetic rat using synchrotron radiation coronary microangiography
| Project/Area Number |
25350879
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SATO Fujio 筑波大学, 医学医療系, 講師 (20375497)
TOKUNAGA Chiho 筑波大学, 医学医療系, 講師 (30451701)
HYODO Kazuyuki 大学共同利用機関法人高エネルギー加速器研究機構, 物質構造科学研究所, 准教授 (60201729)
MATSUSHITA Shonosuke 筑波技術大学, 保健科学部, 教授 (70359579)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 放射光 / 糖尿病 / 冠動脈 / ラット |
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| Outline of Final Research Achievements |
The purpose of this research is to elucidate the feature of coronary artery in diabetic patients. First of all, we developed a system of synchrotron radiation coronary microangiography (SRCA) in the in vivo rat. SRCA can visualize vessels as small as 50 um in diameter, thus enabling us to evaluate the coronary artery reaction in the in vivo rat. After that, SRCA could confirm the microvascular constriction of the coronary arteries in the in vivo rat after endothelin administration and detect 25 um caliber change of coronary artery.
And also, SRCA could confirm that sympathetic nerve stimulation by cold exposure induced coronary vasoconstriction in the in vivo diabetic rat. Average dimeter of all measured coronary arteries after cold exposure was increased by 9% in the normal rat and decreased by 10% in the DM rats. This result suggests that the biological response function of coronary artery against external stress is low in the in vivo diabetic rats.
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| Free Research Field |
心臓血管外科学
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