Study on circulatory disease and arteriosclerosis risk factor in an agriculture area

2016 Fiscal Year Final Research Report

• Project/Area Number: 25350894
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Wakayama Medical University
• Principal Investigator: Mikio Arita 和歌山県立医科大学, 保健看護学部, 名誉教授 (40168018)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 循環器疾患 / 危険因子 / 高血圧 / 起立負荷 / 生活習慣病 / 動脈硬化 / 認知機能障害

Outline of Final Research Achievements

1. We investigated orthostatic blood pressure response and autonomic function at standing. Blood pressure increased with age and pulse pressure and delta blood pressure at standing significantly increased. Sympathetic nerve response at standing , parasympathetic nerve activity at rest and standing decreased with age. Autonomic nerve activity at rest and standing decreased with age. 2. We evaluated the orthostatic BP elevation using a simple standing-up test, and the relationship of orthostatic BP elevation with the atherosclerosis markers and autonomic nervous function in hypertensive subjects. The results show orthostatic BP elevation may be associated with vascular stiffness, central BP and the autonomic nervous function. 3. Long term intervention revealed that salt restriction is effective in reducing blood pressure and urinary Na/K.4. We showed that there are relationship between antihypertensive drugs and mental dysfunction in hypertensive subjects.

Free Research Field

高血圧