2015 Fiscal Year Final Research Report
Inhibiting effect of blood flow restriction on skeletal muscle atrophy and investigation of related genes
| Project/Area Number |
25350899
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAKEI Saori 順天堂大学, 大学院医学(系)研究科(研究院), 特任助教 (00450560)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 血流制限 / 筋萎縮 / 遺伝子発現 |
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| Outline of Final Research Achievements |
Expression levels of genes influencing skeletal muscle protein synthesis and breakdown were analyzed after immobilizing the human lower extremity in a cast as a model of muscle atrophy and weakness to clarify the mechanisms of the preventing effect of repeated local blood flow restriction on muscle atrophy and weakness. It was suggested that the regulation of gene expression level such as MuRF1, FoxO3, p70S6K may be involved in the mechanisms.
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| Free Research Field |
スポーツ医学（運動器系）
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