May the effects of in utero irradiation are involved in future carcinogenesis?

2016 Fiscal Year Final Research Report

• Project/Area Number: 25350956
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Childhood science (childhood environment science)
• Research Institution: National Institutes for Quantum and Radiological Science and Technology
• Principal Investigator: AMASAKI YOSHIKO 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 放射線影響研究部, 研究員(任非) (80435700)
• Co-Investigator(Renkei-kenkyūsha): KAKINUMA SHIZUKO 国立研究開発法人 量子化学技術研究開発機構, 放射線医学総合研究所 放射線影響研究部, 部長 (20392219)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 胎児期 / 放射線 / 複合曝露 / 胸腺リンパ腫

Outline of Final Research Achievements

We studied the combined effect of radiation exposure in utero, with ENU treatment at various times after birth, on T-cell lymphoma development using B6C3F1 mice. Combined radiation exposure with ENU treatment increased the T-cell lymphomas incidence significantly compared to irradiation at either 5 weeks old or E17.
ENU was more efficient at inducing T-cell lymphomas with shorter intervals following irradiation, at either age. These results suggest the effects of in utero irradiation may persist, and that sub-carcinogenic doses may still pose a risk with additional environmental exposures in later life.

Free Research Field

放射線分子生物学