Development of a microliter-scale high-throughput screening system with quantum-dot for amyloid-beta aggregation inhibitors

2015 Fiscal Year Final Research Report

• Project/Area Number: 25350974
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Chemical biology
• Research Institution: Muroran Institute of Technology
• Principal Investigator: TOKURAKU Kiyotaka 室蘭工業大学, 工学(系)研究科(研究院), 准教授 (00332106)
• Co-Investigator(Renkei-kenkyūsha): UWAI Koji 室蘭工業大学, 工学研究科, 准教授 (80347905)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: アミロイド / アルツハイマー / 凝集阻害物質 / スクリーニング / ハイスループット / 量子ドット / イメージング / 認知症

Outline of Final Research Achievements

The aggregation and accumulation of amyloid β protein (Aβ) is a key step in the pathogenesis of Alzheimer’s disease (AD), and therefore Aβ aggregation inhibitors may have preventive and/or therapeutic potential for AD. In this study, we developed a novel microliter-scale high-throughput screening (MSHTS) system for Aβ aggregation inhibitors using quantum-dot. Moreover, we tried to screen Aβ aggregation inhibitors by the MSHTS system from spice and seaweed extracts.

Free Research Field

ケミカルバイオロジー