2015 Fiscal Year Final Research Report
Mechanism of anti-proliferative effect of resveratrol derivatives on cancer cells
| Project/Area Number |
25350979
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical biology
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OKAWARA Tadashi 熊本科学保健大学, 保健科学部, 教授 (60040325)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | レスベラトロール / MIF |
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| Outline of Final Research Achievements |
Derivatives of resveratrol (RVD) that is included in several foods such as grape skin exert anti-proliferative effect on cancer-derived cells. The mode of action regarding to this effect was investigated using molecular biological methods. We found that one inflammatory cytokine called “MIF” interacts with a transcription factor “NFKB”, which down-regulates “JNK”, an apoptosis-inducible signal molecule, thereby avoiding apoptosis induced by reactive oxygen species (ROS). RVDs can prevent MIF from performing this cell protecting effect by direct binding to MIF, resulting in apoptosis. Therefore, RVDs could be promising lead compounds for the development of a therapeutic agents to fight against cancer.
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| Free Research Field |
総合生物
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