2015 Fiscal Year Final Research Report
Assesment of auistic tarit in patients with muscular dystrophy and clinical psychological supports
Project/Area Number |
25380926
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Clinical psychology
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Research Institution | Osaka University |
Principal Investigator |
IMURA OSAMU 大阪大学, 人間科学研究科, 教授 (20176506)
|
Co-Investigator(Renkei-kenkyūsha) |
SAITO TOSHIO 国立病院機構刀根山病院, 臨床研究部, 医師 (60538776)
MATSMURA TSUYOSHI 国立病院機構刀根山病院, 臨床研究部, 医師 (30549366)
FUJIMURA HARUTOSHI 国立病院機構刀根山病院, 臨床研究部, 医師 (20263246)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Keywords | 筋ジストロフィー / 自閉スペクトラム症(ASD) / PARS-SF / SRS / エクソン / アイソフォーム / ジストロフィン遺伝子 |
Outline of Final Research Achievements |
The aim of this study was to investigate the association between the location of mutations in the dystrophin gene and autistic characteristics.Patients with dystrophinopathies (n = 56; mean age = 12.9, SD = 5.2) participated in this study. Autistic characteristics were assessed using PARS-SF and SRS.Eighteen patients (32.1%) showed autistic characteristics by the PARS-SF infantile rating, while 11 patients (19.6%) also scored above the cut-off value on the PARS-SF current rating. Two of seven patients (29%) with mutations in exon 30-44 and five of 25 patients (20%) with mutations in exon 45-55 exceeded the cut-off value in both the infantile and current ratings of PARS-SF, whereas none of the patients with mutations in the exons upstream of exon 30 did so. We found significantly higher ASD characteristics in patients with mutations in exon 45-55 compared to patients with mutations upstream of exon 30.
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Free Research Field |
臨床心理学
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