A neurobehavioral study of ADHD/LD model rats with abnormal neurogenesis in cerebral cortex and/or hippocampus induced by prenatal methylazoxymethanol(MAM) treatment.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25380994
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Experimental psychology
• Research Institution: Himeji Dokkyo University
• Principal Investigator: SUGIOKA KOZO 姫路獨協大学, 医療保健学部, 客員教授 (90112127)
• Co-Investigator(Kenkyū-buntansha): TAKASE KENKICHI 自治医科大学, 医学部, 教授 (80381474)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 注意欠陥多動性障害 / 学習障害 / メチルアゾキシメタノール / 多面的行動分析 / 大脳皮質 / 海馬 / 小脳 / 神経発生学的形態異常

Outline of Final Research Achievements

We developmentally examined the ADHD/LD model rats induced by prenatal methylazoxymethanol (MAM) injection using multiple behavioral tasks (reflex, activity, attention, learning and memory) and histological analysis of the brain from neonatal to adult periods. Behavioral disorders obtained were partially similar to those of human ADHD/LD, and were task-specific, sex-specific, and stage-specific of MAM injection. Our data suggested that these behavioral disorders were related to neuro-genetic cytoarchitectural abnormalities of neocortex, hippocampus and/or cerebellum.

Free Research Field

発達神経行動科学