2015 Fiscal Year Final Research Report
Kinetics of synaptic vesicle filling with neurotransmitter GABA
| Project/Area Number |
25430016
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurophysiology / General neuroscience
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| Research Institution | Doshisha University |
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Principal Investigator |
Hori Tetsuya 同志社大学, 生命医科学部, 准教授 (70396703)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | シナプス小胞 / 前シナプス / GABA / 抑制性シナプス / 小脳 / マウス |
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| Outline of Final Research Achievements |
After releasing neurotransmitter, synaptic vesicles are retrieved by endocytosis and recycled vir fast and slow pathways to be reused for synaptic transmission. To maintai the synaptic efficacy, vesicles must be refilled with neurotransmitter during recycling. We examined the vesicle refilling rate directry at central GABAergic synapses, using caged GABA photolysis. The refilling of vesicles with GABA was about 1 min.
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| Free Research Field |
神経生理学
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