2015 Fiscal Year Final Research Report
Analysis of embryonic-to-adult transition in neural progenitors of the hippocampal granule cells
| Project/Area Number |
25430041
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
Kashiwagi Taichi 東京医科大学, 医学部, 助教 (10398232)
Shinohara Hiroshi 東京医科大学, 医学部, 助教 (10455793)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 海馬 / 神経幹細胞 / 成体脳ニューロン新生 / ニューロン分化 / 移動 / シグナル分子 |
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| Outline of Final Research Achievements |
In the hippocampus, neurons continue to be generated even in adults. The phenomenon of adult neurogenesis raises hopes of regenerating injured brain tissue. In order to understand the persistent neuronal production, we investigate the embryonic-to-postnatal transition of neurogenesis in the hippocampus. We found that the property of neural progenitors is different between embryonic and early postnatal stages. Postnatal and adult progenitors express two stem cell-related proteins, GFAP and BLBP, but embryonic ones express GFAP only. Furthermore, cells surrounding the neurogenic region play an important role in the neurogenesis. They secrete a morphogen, CXCL12, while progenitors have the receptor, CXCR4. The inhibition of the signaling affects differentiation and migration of progenitors. These results suggest that the persistent neurogenesis is involved in alteration of the property of progenitors and a signal molecule secreted by supporting cells around the neurogenic region.
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| Free Research Field |
神経発生学
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