Analysis of neural circuit regulating proliferation of neural precursor cells in the adult SVZ

2015 Fiscal Year Final Research Report

• Project/Area Number: 25430044
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Tottori University (2014-2015); Kansai Medical University (2013)
• Principal Investigator: Mori Tetsuji 鳥取大学, 医学部, 教授 (30285043)
• Co-Investigator(Renkei-kenkyūsha): OKADA Masayoshi 倉敷芸術科学大学, 生命科学部, 教授 (40334677)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 成体ニューロン新生 / 神経幹細胞 / 神経回路

Outline of Final Research Achievements

The subventricular zone (SVZ) in the adult mammalian brain contains neural precursor cells. And it is known that excessive neuronal excitation induces proliferation of neuronal precursor cells. In this study, we showed that epigenetic gene expression is induced in the striatal neurons close to the SVZ immediately after induction of status epilepticus in adult mice. It was suggested that the gene expression change in those neurons led to remodeling of micro-neuronal circuit around the neural precursor cells, and neuronal circuit affects proliferation of neural precursor cells.

Free Research Field

神経解剖学