Mechanism for establishment of the callosal axons from late born cortical neurons

2016 Fiscal Year Final Research Report

• Project/Area Number: 25430046
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Institute for Developmental Research, Aichi Human Service Center
• Principal Investigator: Tabata Hidenori 愛知県心身障害者コロニー発達障害研究所, 神経制御学部, 室長 (80301761)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 神経回路形成 / 神経発生 / 大脳皮質 / 神経幹細胞

Outline of Final Research Achievements

In mammals, the cortical neurons are produced either directly from the neural stem cells in the VZ or secondary proliferative cells in the SVZ. We have previously reported that these two populations undergo distinct migratory behaviors in the late cortical plate development. The former accumulated in the lower SVZ, and then extended callosal axons medially. On the other hand, the latter did not accumulate as seen in the former, but spread widely in the SVZ. In this research project, we hypothesized that these two populations establish distinct axonal connectivity, especially regarding callosal axons. We identified a key gene regulating the production of SVZ-proliferative cells. Overexpression of this molecule enhanced the production of SVZ-proliferative cells. Immunohistochemical analysis revealed that it was expressed in the SVZ-proliferative cells themselves. The further observations how the overexpression of this molecule alter the neural networks are needed.

Free Research Field

神経発生学