2015 Fiscal Year Final Research Report
Regulation of neuronal cell size control in normal and disease condition
| Project/Area Number |
25430064
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAKITA Akiyoshi 新潟大学, 脳研究所, 教授 (80281012)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | mTOR / 細胞サイズ / 神経細胞 / 蛋白合成 / BDNF / AMPK |
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| Outline of Final Research Achievements |
We have analyzed the signaling transduction pathways of mammalian target of rapamycin (mTOR), that is a key enzyme of cell size control. We identified several molecules that regulate the activity of mTOR in neurons. We revealed that activation of mTOR leads to the upregulation of protein and lipid synthesis and its link to the cell size in CNS neurons. In disease study, we found novel somatic mutations of MTOR in Forcal Cortical Dysplasia IIb (FCDIIb) brain and confirm that these mutations make mTOR hyperactive.
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| Free Research Field |
神経化学
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