2015 Fiscal Year Final Research Report
Analysis of molecular mechanisms establishing the circuit connectivity in the cerebellar afferent fibers
| Project/Area Number |
25430073
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 神経回路 / シナプス結合 / 軸索伸展 / 遺伝子発現 |
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| Outline of Final Research Achievements |
We identified cadherin-7 (Cdh7) as a critical regulator of synaptic specificity in the cerebellar mossy fiber circuit between pontine nucleus neurons and cerebellar granule neurons. Cdh7 plays a dual role in target recognition and axonal growth termination to establish the specific synaptic connections in the cerebellar mossy fiber circuit. Several cadherin family members including Cdh7 are expressed in the cerebellar afferent fiber circuits (i.e. mossy fiber and climbing fiber) in a circuit-specific manner and the precise control of their expression is essential to the circuit connectivity. Through combinatorial analysis, some potential candidate regulators for the expression of those cadherins were identified.
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| Free Research Field |
神経発生生物学
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