2015 Fiscal Year Final Research Report
Regulatory mechanisms for endocytosis of presynaptic molecules
| Project/Area Number |
25430074
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Keio University |
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Principal Investigator |
Okuda Takashi 慶應義塾大学, 薬学部, 准教授 (00322040)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | 小胞型トランスポーター / エンドサイトーシス / シグナル配列 |
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| Outline of Final Research Achievements |
A novel assay was devised to search a signal sequence of the clathrin-mediated endocytosis. We found a novel endocytic signal sequence within the N-terminal region of the vesicular GABA transporter VGAT. VGAT is targeted to synaptic vesicles via the clathrin-mediated endocytosis pathway in which this signal sequence is involved.
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| Free Research Field |
神経生化学
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