2015 Fiscal Year Final Research Report
Mechanisms of lipid metabolism system on neural plasticity in brain by ethanol
| Project/Area Number |
25430076
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Hoshi University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | アルコール / 依存症 / 神経可塑性 / 脂質代謝 / モルヒネ |
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| Outline of Final Research Achievements |
Chronic consumption of ethanol has been reported to modify several molecular events in the central nervous system. In this study, chronic treatment with 3% ethanol for 5 days induced up-regulation of hormone-sensitive lipase (HSL) in ventral tegmental area (VTA) of mice. Moreover, phosphatidylinositol were also increased by chronic treatment with ethanol in VTA. Under the condition, the enhanced ethanol-induced place preference after chronic treatment with ethanol was significantly decreased by the intracerebroventricular administration of disulfiram. These results suggest that chronic treatment with ethanol induces amenability to excitation of the mesolimbic dopamine system, which is mediated by changed lipid metabolism. These changes induced by ethanol may influence the susceptibility to drug dependence.
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| Free Research Field |
神経科学、神経薬理学
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