2016 Fiscal Year Final Research Report
Opposing functions of chondroitin sulfate and heparan sulfate in the neural network formation
| Project/Area Number |
25430081
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | Tokyo Metropolitan Institute of Medical Science |
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Principal Investigator |
MAEDA Nobuaki 公益財団法人東京都医学総合研究所, 脳発達・神経再生研究分野, プロジェクトリーダー (90202308)
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| Research Collaborator |
MARUYAMA Chiaki (OHTAKA Chiaki)
SAEGUSA Chika
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Keywords | コンドロイチン硫酸 / ヘパラン硫酸 / プロテオグリカン / 神経筋接合部 / 神経細胞移動 / ショウジョウバエ / プロテオグリカン |
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| Outline of Final Research Achievements |
We analyzed the functions of proteoglycans in the nervous system using two model organisms: Drosophila melanogaster and mouse. We revealed that syndecan (Sdc) and glypican (Dlp) play opposing roles in the neurotransmission at Drosophila neuromuscular junction and in the locomotion of larvae. We also found that Dlp regulates synaptic plasticity at the neuromuscular junction. Furthermore, we found that chondroitin sulfate proteoglycans play critical roles in the neuronal migration and polarization of excitatory neurons in the developing mouse neocortex
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| Free Research Field |
神経科学
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