2015 Fiscal Year Final Research Report
human gene transgenic and knock-down rat model for HIV-1 infection
Project/Area Number |
25430084
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Laboratory animal science
|
Research Institution | Hokkaido University |
Principal Investigator |
shida Hisatoshi 北海道大学, 遺伝子病制御研究所, 客員教授 (00144395)
|
Co-Investigator(Kenkyū-buntansha) |
Zhang Xianfeng 北海道大学, 遺伝子病制御研究所, 助教 (40374681)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Keywords | HIV-1 / 感染 / ラットモデル |
Outline of Final Research Achievements |
To accelerate development of anti HIV-1 vaccine and therapeutics, a rat HIV-1 infection model is useful. We have already found macrophages of rats that express human CD4, CCR5, CyclinT1 and CRM1 genes are efficiently infected with HIV-1. Here we show that the rat T cells whose CyclophilinA and Apobec3 genes are knocked out allow HIV-1 propagation.
|
Free Research Field |
ウイルス学
|