2015 Fiscal Year Final Research Report
The Roles of HSF2 Complex in Huntington's disease mice.
| Project/Area Number |
25430090
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
HAYASHIDA Naoki 山口大学, 医学(系)研究科(研究院), 講師 (40420517)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | HSF2 / Set1/MLL 複合体 / H3K4 / alphaB-クリスタリン / プロモーター / メチル化 / 遺伝子活性化 / ハンチントン病マウス |
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| Outline of Final Research Achievements |
We discovered the novel functions of HSF2. We already published a few data in Hayashida, BBRC 2015.
We also discovered Se1/MLL complex, this complex is methylates H3K4 and avtivates many genes, binds to HSF2. We previously used Huntington's disease model mice and found alphaB-crystallin (CRYAB) is important, therefore, we analyzed the CRYAB promoter. HSF2 and Set1/MLL complex bound to the promoter under both normal and heta-stressed conditions. However, the binding of Set1/MLL complex depends on HSF2. We already HSF2 is critical factor in the survival of Huntington's mice (Shinkawa, Hayashida et al., MBC 2011), This time, we successfully reveraled the novel mechanism why the life span of Huntington's disease mice become prominently shortened.
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| Free Research Field |
老化学
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