2015 Fiscal Year Final Research Report
Research of sphingolipids as a novel tumor marker for clinical study
| Project/Area Number |
25430135
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor diagnostics
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 腫瘍マーカー / 脂質メディエーター / メタボローム解析 / アミノ酸 |
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| Outline of Final Research Achievements |
Using the quantitative method of high sensitivity mass spectrometry for sphingolipid, healthy subjects and blood sphingolipid of each cancer patient was analyzed quantitatively. Especially, it was investigated clinical applicability as a novel tumor marker of SlP. Plasma S1P concentrations were 410±67 nM, 620±129 nM, 484±151 nM, and 491±106 nM in healthy, esophageal cancer, stomach cancer, sarcoma, respectively. Esophageal cancer patient plasma S1P concentration was for the first time revealed that it is significantly higher compared to the healthy subjects. Using metabolome analysis profiling for cancer disease analysis as some new biomarker candidates, in particular, I found the possibility of cystine.
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| Free Research Field |
腫瘍薬学
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