2015 Fiscal Year Final Research Report
Development of novel tumor markers for renal cell carcinoma by evaluating small nuclear acid in blood
| Project/Area Number |
25430137
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor diagnostics
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOJIMA SATOKO 帝京大学, 医学部, 准教授 (10345019)
SEKI NAOHIKO 千葉大学, 大学院医学研究院, 准教授 (50345013)
ENOKIDA HIDEKI 鹿児島大学, 医歯学域医学系, 准教授 (80347103)
NAKAGAWA MASAYUKI 鹿児島大学, 医歯学域医学系, 教授 (90164144)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | マイクロRNA / 腎細胞癌 / 腫瘍マーカー |
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| Outline of Final Research Achievements |
We focused on miR-200s (miR-200a/miR-200b/miR-429 cluster and miR-200c/miR-141cluster). ZEB1/2 genes that are key molecules for EMT were repressed by miR-200s transfection. miR-138 targeted Vimentin which was under stream of ZEB1/2. Tumor suppressive miR-29s repressed LOXL2 and lead to instability of ECM. These microRNAs could be a biomarker of renal cell carcinoma.
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| Free Research Field |
マイクロRNA
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