Analysis of human samples for developing a novel therapy that target the Warburg effect

2015 Fiscal Year Final Research Report

• Project/Area Number: 25430163
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor therapeutics
• Research Institution: Miyagi Prefectural Hospital Organization Miyagi Cancer Center
• Principal Investigator: SATO IKURO 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), ティッシュバンクセンター, センター長 (50225918)
• Co-Investigator(Kenkyū-buntansha): TANUMA NOBUHIRO 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 主任研究員 (40333645) ; ITO SHIGEMI 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (80600006)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: がん / 代謝 / ワールブルグ効果

Outline of Final Research Achievements

It is widely known that cancer cells have lower rates of TCA cycle and oxidative phosphorylation, but less is known about its significance. Here we analyzed human samples for metabolites levels of tumor and corresponding non-cancerous tissues by CE-MS. Lung tumor and normal lung tissue showed differential responses to ischemia in terms of their lactate levels. Our results may be a first report observing the Warburg effect of human patients.

Free Research Field

腫瘍学