2015 Fiscal Year Final Research Report
Study of functional structure of protein and biomembrane by the developement of resonant X-ray solution scattering in wide-energy range
| Project/Area Number |
25440063
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biophysics
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| Research Institution | Gunma University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | X線散乱 / タンパク質 / 生体膜 / 共鳴散乱 |
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| Outline of Final Research Achievements |
The use of anomalous dispersion of X-ray (resonant X-ray scattering) is expected to serve us a new insight on functional structures of proteins and membrane in solutions, especially of metalloproteins proteins containing metal atoms or clusters that are involved in a wide range of important biological processes. On the other hand, the recent development of the wide-angle X-ray scattering technique of proteins and membrane using third-generation synchrotron sources shows us that the X-ray solution scattering enables to observe a whole hierarchical structure ranging from ~0.2 nm to ~250 nm, namely, from the secondary structure to the quaternary one of proteins or from the alkylchain packing to the whole structure of lipid aggregate.
The aim of this study was the development of the new method for studying the internal structure of biological material in-situ by the combination of resonant and wide-angle scattering of X-ray.
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| Free Research Field |
生物物理学
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