2015 Fiscal Year Final Research Report
Investigation of membrane trafficking for HCV biogenesis
| Project/Area Number |
25440077
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Osaka University |
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Principal Investigator |
Itoh Takashi 大阪大学, 歯学研究科(研究院), 助教 (50373270)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Keywords | オートファジー / LC3結合タンパク質 / 基質認識 |
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| Outline of Final Research Achievements |
Autophagy is a degradation system required for keeping intracellular homeostasis, eliminating insoluble protein aggregates and damaged organelle. Since excess and insufficient activity of autophagy lead to defect of the homeostasis, the regulation of autophagic activity is important. In addition, the proper recognition of substrates for degradation is also essential for maintaining the homeostasis. Here, I showed that the same molecule is used in the regulation of activity and the recognition of substrates but the way of usage is different each other.
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| Free Research Field |
細胞生物学
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