2015 Fiscal Year Final Research Report
Molecular basis of memory impairment related to life-span extending treatments in insect
| Project/Area Number |
25440163
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 加齢性記憶障害 / 嗅覚学習 / 長期記憶 / 一酸化窒素 / メラトニン / 昆虫 |
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| Outline of Final Research Achievements |
We have previously reported that LTM formation ability of crickets decline along with aging. In the present study, I demonstrated how three types of candidate life-span extending treatments affect the actual life-span and ability of LTM formation in crickets. Rearing the crickets under a low-temperature environment lead to extension in life-span along with sustained LTM formation ability. Mating restriction also extended the life-span but with impairment in LTM formation ability much earlier than the control group. Chronic administration of melatonin did not significantly extend the life-span, but LTM formation ability was conserved longer. I also found that single-injection of melatonin recovered the LTM formation ability in aged crickets, indicating the participation of melatonin in LTM formation process.
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| Free Research Field |
生物学
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