Background mechanism of Hepatocyte Growth Factor and Atherosclerosis in relation to Environmental Factors.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25440255
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied anthropology
• Research Institution: Nagasaki University
• Principal Investigator: NAKAZATO Mio 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (00380973)
• Co-Investigator(Kenkyū-buntansha): SHIMIUZU Yuji 長崎大学, 医歯薬学総合研究科(医学系), 講師 (40569068)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 肝細胞増殖因子 / 高血圧 / 動脈硬化

Outline of Final Research Achievements

We measured the values of hepatocyte growth factor (HGF) in 1486 subjects who were undertaking a general health check-up. To evaluate the activity of bone marrow we focused on hemoglobin values and found that hemoglobin is significantly positively associated with hypertension and atherosclerosis. Since HGF is reported to be act as a potential index of severity of hypertension, we investigated the correlation between HGF and hemoglobin. The result of our present study showed that for both men and women hemoglobin is significantly positively correlated with HGF among hypertensive subjects but not among non-hypertensive subjects. Those results support hemoglobin as an efficient tool to evaluate vascular damage induced by hypertension in daily medical practice because hemoglobin can easily be measured.

Free Research Field

応用人類学