2015 Fiscal Year Final Research Report
Stereocontrolled Synthesis of nitrogen-containing polycyclic scaffolds using axially chiral ortho-azaxylylene intermediate
| Project/Area Number |
25450151
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bioorganic chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
NAKAZAKI Atsuo 名古屋大学, 生命農学研究科, 准教授 (00366428)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | ortho-アザキシリレン / 含窒素化合物 / 不斉合成 / 立体制御 / 3,3-二置換オキシインドール / 軸不斉 |
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| Outline of Final Research Achievements |
In this study, we explored two issues for the synthesis of nitrogen-containing polycyclic natural products: 1) stereoselective synthesis of 3,3-disubstituted oxindoles having a C3-quaternary stereogenic center via a chiral ortho-azaxylylene intermediate, and 2) catalytic asymmetric synthesis of N-aryl isatin. Our result allows us to synthesize a wide variety of oxindoles having substituents which can be seen in polycyclic alkaloids.
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| Free Research Field |
農学
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