2015 Fiscal Year Final Research Report
Up-regulation of cellular telomerase activity by Amadori-glycated phosphatidylethanolamine: a link between diabetes and cancer
| Project/Area Number |
25450185
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Nigata University of Phermacy and Applied Life Sciences |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 糖尿病 / 癌 / テロメラーゼ / 糖化脂質 |
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| Outline of Final Research Achievements |
Numerous epidemiologic studies suggest that type 2 diabetes significantly increases cancer risk. Amadori-glycated phosphatidylethanolamine (Amadori-PE) plays a key role in the development of diabetic complications. We hypothesized that Amadori-PE may participate not only in the pathogenesis of diabetic complications but also in tumor progression. In the present study, this hypothesis was investigated in cell-culture study, with particular emphasis on the effect of Amadori-PE on telomerase activity which contributes to the infinite replicative potential of cancer cells. Amadori-PE activated MAPK pathway by inducing oxidative stress, leading to up-regulation of c-Myc and hTERT expressions, thereby increasing cellular telomerase activity. Telomerase activity was decreased by a combination treatment of Amadori-PE and alpha-tocopherol, an antioxidant vitamin. These results provide experimental evidence for a novel role of lipid glycation in linking diabetes and cancer.
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| Free Research Field |
食品科学
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