Adaptive immune system in teleost peritoneal cavity

2015 Fiscal Year Final Research Report

• Project/Area Number: 25450307
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Aquatic life science
• Research Institution: Fukui Prefectural University
• Principal Investigator: SUETAKE Hiroaki 福井県立大学, 海洋生物資源学部, 准教授 (00334326)
• Co-Investigator(Kenkyū-buntansha): MIYADAI Toshiaki 福井県立大学, 海洋生物資源学部, 教授 (20157663)
• Research Collaborator: ODAKA Tomoyuki ; SAITO Takumi ; MARUYAMA Ami ; CHUJO Taro ; MAEDA Tomoki
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ワクチン / 免疫 / フグ

Outline of Final Research Achievements

Vaccination is one of the most effective ways to prevent fish diseases in aquaculture. The vaccination is based on adaptive immune system, but how the system is activated in the fish peritoneal cavity is still unknown.
First, we examined the composition of fugu peritoneal cavity leukocytes. The biggest population was B cells that produce antibody, and the second one was macrophages. Next, we cultured the peritoneal leukocytes with insoluble substance. Both macrophages and B cell took up the substance. At last, we demonstrated that the chemokine secreted from the peritoneal macrophages attracted the peritoneal B cells. Thus, interaction of B cells and macrophages in the fish peritoneal cavity play an important role in fish adaptive immune system.

Free Research Field

魚類生理学