Pathogenicity of Helicobacter species and role for development of inflammatory bowel disesases

2015 Fiscal Year Final Research Report

• Project/Area Number: 25450444
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Veterinary medical science
• Research Institution: Nagasaki University
• Principal Investigator: YAMANAKA Hitoki 長崎大学, 先導生命科学研究支援センター, 助教 (30533921)
• Co-Investigator(Kenkyū-buntansha): MASUYAMA Ritsuko 長崎大学, 医歯薬学総合研究科(歯学系), 准教授 (60297596) ; OHSAWA Kazutaka 長崎大学, 先導生命科学研究支援センター, 教授 (90244756)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: ヘリコバクター属菌 / 大腸粘膜 / 盲腸粘膜 / 粘膜固有層リンパ球 / ヘルパーT細胞反応 / 感染防御機構 / 生殖器 / ATP分泌性腸球菌

Outline of Final Research Achievements

Many Helicobacter species indicate pathogenicity and novel speceis have been isolated recently. The purpose of this study was characterization and clarifying the pathogenicity of unclassified species, MIT01-6451, detected frequently in laboratory mice.
The morphological and biochemical characterization of MIT01-6451 were demonstrated and its clonization sites were clarified which were cecum and colon of mice. Since MIT01-6451 infection in immunodeficient mice induced necrosis in liver and abnormal delivery, our study indicated that MIT01-6451 shows pathogenicity in hepatic and reproductive tissues other than intestine. The infection in immunodeficient mice also showed rectal prolapse and inflammation in cecal and colonic mucosa. In immunocompetent mice, although the clinical symptoms were not observed, inflammatory and various Th resoponses were detected in lymphocytes of cecal and colonic mucosa. A part of mechanisms of MIT01-6451 pathogenicity in mice were clarified in this study.

Free Research Field

実験動物感染症、細菌性人獣共通感染症