Analysis of the imprinted genes regulating Cdx2 expression in mouse trophoblast stem cells.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25450470
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Integrative animal science
• Research Institution: Tokyo University of Agriculture
• Principal Investigator: Ogawa Hidehiko 東京農業大学, 応用生物科学部, 教授 (20339089)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 胎盤形成 / 栄養膜幹細胞 / 雌雄ゲノム / 発生・分化 / 遺伝子発現制御

Outline of Final Research Achievements

To clarify the function of parental genomes for the placentation in mice, the regulation of Cdx2 expression in trophoblast stem cells derived from androgenetic embryos (ATS cells) has been examined. CDX2-positive giant cells were detected in ATS cells. Moreover, Cdx2 was expressed via MEK-ERK and non-MEK-ERK pathway. These unique characteristics in ATS cells may provide the novel information to understand the function of parental genomes for Cdx2 expression.

Free Research Field

動物発生工学